Flaum Eye Institute
James Aquavella, MD
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AB Johns Hopkins University MD University of Naples Contact Information: E-Mail: james_aquavella@urmc.rochester.edu University of Rochester Ophthalmology M & D 601 Elmwood Ave, Box 659 Rochester, New York 14642 Phone: (585) 275-8944 Fax: (585) 276-0292 |
Research Interests
OCULAR SURFACE TEAR FILM
Our goal is to understand the dynamic role of the ocular surface tear film. Qualitative and quantitave tear film dysfunction affects 60 million individuals in the US alone. Despite advances in our understanding of dry eye disease, there remains no single objective test for the diagnosis of dry eye. We are developing three different imaging modalities that allow for the objective and noninvasive tear film examinations and make it possible to investigate temporal changes in tear film chacteristics in real time.
We have constructed a chamber in which we control temperature, humidity, and air flow independently; and also monitor blink rate and ocular motility. By introducing our objective techniques into the controlled adverse environment chamber we have created a powerful and unique tool to establish dynamic ranges, differentiate dry eyes from normals,determine variations in symptomatology, and evaluate specific therapeutic modalities.
DRUG DELIVERY
We are interested in evaluating the therapeutic efficacy of new drugs. Oue goal is to establish the relationship between objective findings and symptomatology under controlled and reproductive circumstances. We intend to identify those therapeutic modalities that can clinical efficacy insubsequent clinical trials.
Aquavella Lab
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Selected Publications
Aquavella JV. Pediatric keratoprosthesis: A new surgical approach. Ann Ophthalmol (Skokie). 2008;40:64-67.
Aquavella JV. Keratoprosthesis in the treatment of severe ocular trauma. Can J Ophthalmol. 2008;43:153-155.
Palakuru JR, Wang J, Aquavella JV. Effect of blinking on tear volume after instillation of midviscosity artificial tears. Am J Ophthalmol. 2008;146:920-924.
Wang J, Palakuru JR, Aquavella JV. Correlations among upper and lower tear menisci, noninvasive tear break-up time, and the schirmer test. Am J Ophthalmol. 2008;145:795-800.
Wang J, Simmons P, Aquavella J, et al. Dynamic distribution of artificial tears on the ocular surface. Arch Ophthalmol. 2008;126:619-625.
Akpek EK, Harissi-Dagher M, Petrarca R, et al. Outcomes of boston keratoprosthesis in aniridia: A retrospective multicenter study. Am J Ophthalmol. 2007;144:227-231.
Aquavella JV, Gearinger MD, Akpek EK, McCormick GJ. Pediatric keratoprosthesis. Ophthalmology. 2007;114:989-994.
Coassin M, Zhang C, Green WR, Aquavella JV, Akpek EK. Histopathologic and immunologic aspects of alphacor artificial corneal failure. Am J Ophthalmol. 2007;144:699-704.
Khan BF, Harissi-Dagher M, Pavan-Langston D, Aquavella JV, Dohlman CH. The boston keratoprosthesis in herpetic keratitis. Arch Ophthalmol. 2007;125:745-749.
Palakuru JR, Wang J, Aquavella JV. Effect of blinking on tear dynamics. Invest Ophthalmol Vis Sci. 2007;48:3032-3037.
Williams ZR, Aquavella JV. Management of exposure keratopathy associated with severe craniofacial trauma. J Cataract Refract Surg. 2007;33:1647-1650.
Aquavella JV, Qian Y, McCormick GJ, Palakuru JR. Keratoprosthesis: Current techniques. Cornea. 2006;25:656-662.
Wang J, Aquavella J, Palakuru J, Chung S. Repeated measurements of dynamic tear distribution on the ocular surface after instillation of artificial tears. Invest Ophthalmol Vis Sci. 2006;47:3325-3329.
Wang J, Aquavella J, Palakuru J, Chung S, Feng C. Relationships between central tear film thickness and tear menisci of the upper and lower eyelids. Invest Ophthalmol Vis Sci. 2006;47:4349-4355.
Aquavella JV, Qian Y, McCormick GJ, Palakuru JR. Keratoprosthesis: The dohlman-doane device. Am J Ophthalmol. 2005;140:1032-1038.
Nomura K, Singer DE, Aquavella JV. Corneal sensation after topical anesthesia. Cornea. 2001;20:191-193.
Hanuch OE, Agrawal VB, Bassage S, del Cerro M, Aquavella JV. Myopic picosecond laser keratomileusis with the neodymium-yttrium lithium fluoride laser in the cat cornea. Ophthalmology. 1998;105:142-149.
Agrawal VB, Hanuch OE, Bassage S, Aquavella JV. Alcohol versus mechanical epithelial debridement: Effect on underlying cornea before excimer laser surgery. J Cataract Refract Surg. 1997;23:1153-1159.
Hanuch OE, Agrawal VB, Papernov S, del Cerro M, Aquavella JV. Posterior capsule polishing with the neodymium:YLF picosecond laser: Model eye study. J Cataract Refract Surg. 1997;23:1561-1571.
Itoi M, Ryan R, Depaolis M, Aquavella JV. Clinical effect of blowing nitrogen gas across the cornea during photorefractive keratectomy. J Refract Surg. 1997;13:69-73.
Itoi M, Bassage S, del Cerro M, Aquavella JV. Corneal incisions utilizing the 1,053-nm picosecond nd:YLF ophthalmic laser. Cornea. 1996;15:2-8.
Zuckerman SJ, Aquavella JV, Park SB. Analysis of the efficacy and safety of excimer laser PTK in the treatment of corneal disease. Cornea. 1996;15:9-14.
Erickson DB, Ryan RA, Erickson P, Aquavella JV. Cognitive styles and personality characteristics strongly influence the decision to have photorefractive keratectomy. J Refract Surg. 1995;11:267-74; discussion 274-81.
Loya N, Bassage S, Vyas S, Park SB, del Cerro M, Aquavella JV. Effects of the picosecond neodymium:YLF laser on poly(methyl methacrylate) intraocular lenses during experimental posterior capsulotomy. J Cataract Refract Surg. 1995;21:586-590.
You X, Bergmanson JP, Zheng XM, MacKenzie IC, Boltz RL, Aquavella JV. Effect of corticosteroids on rabbits corneal keratocytes after photorefractive keratectomy. J Refract Surg. 1995;11:460-467.