Flaum Eye Institute

Assistant Professor of Ophthalmology

The Eye Institute welcomes Alfredo Dubra, Ph.D., to the research faculty. He joins UREI as assistant professor of ophthalmology after finishing his post-doctoral fellowship under the Center for Visual Science's David Williams. Dr. Dubra completed his doctorate in physics at the prestigious Blackett Laboratory of Imperial College, London, and is a 2007 winner of a Burroughs Wellcome Fund Career Award for his research proposal, Understanding eye disease through structural and functional in vivo cellular imaging of the retina. Dr. Dubra's research will focus on applying advanced microscopy techniques to visualize retinal structure and function in novel ways, with the aim of increasing the sensitivity and specificity of eye disease diagnosis. Emphasis will center on developing better screening methods for glaucoma by noninvasively imaging retinal ganglion cells (RCGs). Visualizing RCGs is important for early diagnosis of glaucoma, before it causes irreversible vision loss to the patient. The technology will also help drug companies evaluate the performance of new treatments for the disease.

Selected Publications

Study of the tear topography dynamics using a lateral shearing interferometer. A. Dubra, C. Paterson and C Dainty, Opt. Exp., 12 (25) : 6278-6288, 2004.

Double-lateral shearing interferometer for the quantitative measurement of the tear film topography. A. Dubra, C. Paterson and C Dainty, App. Opt., 44 (7) : 1-9, 2005.

In vivo fluorescence imaging of primate retinal ganglion cells and retinal pigment epithelial cells.
Daniel C. Gray, William Merigan, Jessica I. Wolfing, Bernard P. Gee, Jason Porter, Alfredo Dubra, Ted H. Twietmeyer, Kamran Ahamd, Remy Tumbar, Fred Reinholz, and David R. Williams, Opt. Exp., 14 (16) : 7144-7158, 2006.

In vivo imaging of the fine structure of rhodamine-labeled macaque retinal ganglion cells.
Daniel C. Gray, Robert Wolfe, Bernard P. Gee, Drew Scoles, Ying Geng, Benjamin D. Masella, Alfredo Dubra, Sergio Luque, David R. Williams, and William H. Merigan,
IOVS, 49 (1) : 467-473, 2008.

In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic.
Jessica I. Morgan, Alfredo Dubra, Robert Wolfe, William Merigan and David R. Williams. IOVS, 50 (3) : 1350-1359, 2008.

In vivo imaging of microscopic structures in the rat retina. Ying Geng, Kenneth P. Greenberg, Robert Wolfe, Daniel C. Gray, Jennifer J. Hunter, Alfredo Dubra, John G. Flannery, David R. Williams and Jason Porter, IOVS, in press.