Flaum Eye Institute

Lin Gan, Ph.D.

Professor of Ophthalmology
Neurobiology and Anatomy
Center for Visual Science
Center for Neural Development and Disease

Publications

Gan Lab Links Home Research Team Publications, Presentations & Patents Honors & Grants

1. Gan, L., Zhang, W., and Klein, W.H. (1990). Repetitive DNA sequences linked to the sea urchin Spec genes contain transcriptional enhancer-like elements. Developmental Biology 139, 186-196.

2. Gan, L., Wessel, G.M., and Klein, W.H. (1990). Regulatory elements from the related Spec genes of Strongylocentrotus purpuratus yield different spatial patterns with a lacZ reporter gene. Developmental Biology 142, 346-358. (cover photograph)

3. Klein, W.H., Tomlinson, C.R., Zhang, W., Xiang, M., Kozlowski, M.T., Gan, L., Nguyen, T., and Wessel, G.M. (1990). Ectoderm differentiation and the Spec gene family of sea urchin. In Developmental biology, UCLA Symposium on Molecular and Cellular Biology, New Series, Vol. 125, 123-134.

4. Kozlowski, M.T., Gan, L., Venuti, J.M., Sawadogo, M., and Klein, W.H. (1991). Sea urchin USF: a helix-loop-helix protein active in embryonic ectoderm cells. Dev. Biol. 148, 625-630.

5. Venuti, J.M., Gan, L., Kozlowski, M.T., and Klein, W.H. (1993). Developmental potential of muscle cell progenitors and the myogenic factor SUM-1 in the sea urchin embryo. Mechanisms of Development 41, 3-14. (cover photograph)

6. Gan, L. and Klein, W.H. (1993). A positive cis -regulatory element with a bicoid -target site lies within the sea urchin Spec2a enhancer. Developmental Biology 157,119-132.

7. Mao, C-A., Gan, L., and Klein, W.H. (1994). Multiple Otx-binding sites required for expression of the Strongylocentrotus purpuratus Spec2a gene, Developmental Biology 165, 229-242.

8. Gan, L., Mao, C-A., Wikramanayake, A.H., Angerer, L.M., Angerer, R.C., and Klein, W.H. (1995). An orthodenticle-related protein from Strongylocentrotus purpuratus. Developmental Biology 167, 517-528.

9. Mao, C-A., Wikramanayake, A.H., Gan, L., Chuang, C-K., and Klein, W.H. (1996). Altering cell fates in sea urchin embryos by overexpressing SpOtx, an orthodenticle-related protein. Development 122, 1489-1498.

10. Gan, L., Xiang, M., Zhou, L., Wagner, D.S., Klein, W.H., and Nathans, J. (1996). POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proceedings of the National Academy of Science 93, 3920-3925.

11. Xiang, M.*, Gan, L.*, Zhou, L., Klein, W.H., and Nathans, J. (1996). Targeted deletion of the mouse POU domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired sucking. Proceedings of the National Academy of Science 93, 11950-11955. (*equal contribution)

12. Klein, W.H., Mao, C-A., Gan, L., Chuang, C-K., and Wikramanayake, A.H. (1997). Manipulating cell fates in the sea urchin embryo . In Invertebrate Reproduction and Development 31:1-3, 21-29.

13. Xiang, M., Gan, L., Li, D., Zhou, L., Chen, Z., Wagner, D., O'Malley Jr., B.W., Klein, W., and Nathans, J. (1997). Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems. In Cold Spring Harbor Symposium on Quantitative Biology, Vol. LXII, 325-336.

14. Xiang, M.*, Gan, L.*, Li, D.*, Chen, Z., Zhou, L., O'Malley Jr., B.W., Klein, W, and Nathans, J. (1997). Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proceedings of the National Academy of Science 94, 9445-9450. (*equal contribution)

15. Chen, H., Lun, Y., Ochinnikov, D., Kokubo, H., Oberg, K. C., Pepiclli, C. V., Gan, L., Lee, B., and Johnson, R.J. (1998). Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella symdrome. Nature Genetics 19, 51-55.

16. Evrard, Y.A., Lun, Y., Aulehla, A., Gan, L. and Johnson, R.L. (1998). Lunatic fringe is an essential mediator of somite segmentation and patterning. Nature 394, 377-381.

17. Wagner, D.S., Gan, L., and Klein, W.H. (1998). Expression of a gene trap reporter construct in a subset of cells in embryonic sites of hematopoiesis: Evidence for alternative rRNA production in hematopoietic cells. Biochemical Biophysical Research Communication 250, 674-681.

18. Lin, X., Gan, L., Klein, W.H., and Wells, D. (1998). Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene. Biochemical Biophysical Research Communication 248:738-743.

19. Vivian, J.L., Gan, L., Olson, E.N., and Klein, W.H. (1999). Threshold levels of myogenin required for viability, skeletal muscle differentiation, and sternum formation revealed through a hupomorphic myogenin allele. Developmental Biology 208, 44-55.

20. Gan, L.*, Wang, S.W., Huang, Z., and Klein, W.H.* (1999). POU-domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specificatioon or migration. Developmental Biology 210, 469-480. (*Co-corresponding)

21. Wagner, D.S., Gan, L., and Klein, W.H. (1999). Identification of a differentially expressed RNA helicase by gene trapping. Biochemical Biophysical Research Communication 262, 677-684.

22. Wang, S.W., Gan, L., Martin, S.E., and Klein, W.H. (2000). Abnormal polarization and axon outgrowth in retinal ganglion cells lacking the POU-domain transcription factor Brn-3b. Moledular & Cellular Neuroscience 16, 141-156. (cover photograph)

23. Lu, J., Chang, P., Richardson, J.A., Gan, L., Weiler, H., Olson, E.N. (2000). The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. Proceedings of the National Academy of Science USA. 97, 9525-9530.

24. Eng, S.R., Gratwick, K., Rhee, J.M., Fedtsova, N., Gan, L., and Turner, E.E. (2001). Defects in sensory axon guidance precede neuronal death in brn-3a-deficient mice. Jornal of Neuroscience 21, 541-549.

25. Wang, S.W., Kim, B.S., Ding, K., Wang, H., Sun, D., Johnson, R.L, Klein, W.H. and Gan, L. (2001). Requirement of math5 in the development of retinal ganglion cells. Genes & Development 15, 24-29.

26. Kim, B.S., Savinova, O.V., Reedy, M.V., Martin, J., Lun, Y., Gan, L., Smith, R.S., Tomarev, S.I., John, S.W., and Johnson, R.L. (2001) Targeted disruption of the myocilin gene (Myoc) suggests that human glaucoma-causing mutations are gain of function. Molecular & Cellular Biology 21, 7707-7713.

27. Mu, X., Zhao, S., Pershad, R., Tzung-Fu Hsieh, T-F., Scarpa, A., Wang, S.W., White, R.A., Thomas, T.L., Gan, L., and Klein, W.H. (2001). Analysis of the Transcriptome for the Developing Mouse Retina. Nucleic Acids Research 24, 4983-4993.

28. Wang, S.W., Mu, X., Kim, D.D., Bowers, W., Plas, D.J., Crair, M., Federoff, H.J., Gan, L., and Klein, W.H. (2001). Brn-3b-Brn-3c double knockout mice reveal a requirement for Brn-3c in murine retinal ganglion cell differentiation. Development 129, 467-77.

29. Guo, Z., Clydesdale, G., Cheng, J., Kim, K., Gan, L., McConkey, D.J., Ullrich, S.E., Zhuang, Y., and Su, B. (2002). Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. Molecular & Cellular Biology 22, 5761-5768.

30. Yeh, S., Tsai, M.Y., Xu, Q., Mu, X.M., Lardy, H., Huang, K.E., Lin, H., Yeh, S.D., Altuwaijri, S., Zhou, X., Xing, L., Boyce, B.F., Hung, M.C., Zhang, S., Gan, L., and Chang, C. (2002). Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proceedings of the National Academy of Science USA 99, 13498-13503.

31. Wee, R., Castrucci, A.M., Provencio, I., Gan, L., Van Gelder, R.N. (2002). Loss of photic entrainment and altered free-running circadian rhythms in math5-/- mice. Journal of Neuroscience. 22, 10427-10433.

32. Lu, J., Bassel-Duby, R., Hawkins, A., Chang, P., Valdez, R., Wu, H., Gan, L., Shelton, J.M., Richardson, J.A., and Olson, E.N. (2002). Control of facial muscle development by MyoR and Capsulin. Science 298, 2378-2381

33. Yang, Z., Ding, K., Pan, L., Deng, M., and Gan, L. (2003). Math5 determines the competence state of retinal ganglion cell progenitors. Developmental Biology 264, 240-254.

34. Yan, D.-H., Wen, Y., Su, L.-K., Xia, W., Wang, S.-C., Zhang, S., Gan, L., Lee, D.-F., Frey J. A., Hortobagyi, G. N. and Hung, M.-C. (2004). A delayed chemically-induced tumorigenesis in Brca2 mutant mice. Oncogene 23, 1896-1901.

35. Radde-Gallwitz, K., Pan, L., Gan, L., Lin, X., Segil, N., and Chen, P. (2004). Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear. Journal of Comparative Neurology 477, 412 - 421.

36. Pan, L., Yang, Z., Feng, L., and Gan, L. (2005). Functional Equivalence of Brn-3 POU-Domain Transcription Factors in Mouse Retinal Neurogenesis. Development 132, 703-712. (cover photograph)

37. Xie, J., Lu, L., Deng, M., Weng, S., Zhu, J., Wu, Y., Gan, L., Chan, S.M., and He, J. (2005). Inhibition of reporter gene and Iridovirus-tiger frog virus in fish cell by RNA interference. Virology 338, 43-52.

38. Deng, M., Pan, L., Xie, X., and Gan, L. (2006). Differential Expression of LIM Domain-Only (LMO) Genes in the Developing Mouse Inner Ear. Gene Expression Patterns 6, 857-863.

39. Feng, L., Xie, X., Joshi, P., Yang, Z., Shibasaki, K., Chow, R., and Gan, L. (2006). Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina. Development 4815-4825. doi:10.1242/dev.02664 (cover photograph)

40. Shibasaki, K., Takebayashi, H., Ikenaka, K., Feng, L., and Gan, L. (2007). Expression of the basic helix-loop-factor Olig2 in the developing retina: Olig2 as a new marker for retinal progenitors and late-born cells. Gene Expression Patterns 7, 57-65.

41. Elshatory, Y., Deng, M., Xie, X., and Gan, L. (2007). Expression of the LIM-homeodomain protein Isl1 in developing mouse retina: evidence for a role in the neuronal differentiation of retinal bipolar, amacrine and ganglion cells. Journal of Comparative Neurology. 503, 182–197. DOI 10.1002/cne.21390

42. Elshatory, Y., Deng, M., Xie, X., Barlow, R.B., and Gan, L. (2007). Isl1 regulates the differentiation pathway of retinal ON-bipolar cells. Journal of Neuroscience 27:12707-12720; doi:10.1523/JNEUROSCI.3951-07.2007

43. Pan, L., Deng, D., Xie, X., and Gan, L. (2008). ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells. Development 135, 1981-1990. doi: 10.1242/dev.010751. (cover photograph).

44. Elshatory, Y. and Gan, L. (2008). The LIM-Homeobox Gene Islet-1 Is Required for the Development of Restricted Forebrain Cholinergic Neurons. J. Neurosci. 28:3291–3297. DOI:10.1523/JNEUROSCI.5730-07.2008

45. Joshi, P.S., Molyneaux, B.J., Feng, L., Xie, X., Macklis, J., and Gan, L. (2008). Bhlhb5 Regulates the Post-Mitotic Acquisition of Area Identities in Layers II-V of the Developing Neocortex. Neuron 60, 258–272. doi:10.1016/j.neuron.2008.08.006