Urology
Urological Conditions
Treatment of Interstitial Cystitis
Bladder Instillation
This procedure consists of filling the bladder not with water, but with a medication in liquid form. In other words, the drug is delivered directly into the bladder, rather than being taken orally. It’s delivered through a catheter, a very thin tube, that is inserted into and up the urethra into the bladder. Usually, the solution stays in the bladder for about 15 minutes or so, and is then expelled.
Currently, the only FDA approved drug for this purpose is dimethyl sulfoxide (DMSO, Rimso-50®), which seems to act as an anti-inflammatory. Sometimes dimethyl sulfoxide is mixed with other medications, such as heparin, steroids or local anesthetics. Treatments are given every week or two during a six to eight week period. This cycle can be repeated if needed. Usually, patients notice improvement a few weeks (3-4) after their fist cycle. Side effects are rare, but may include a garlicky taste and smell on the skin and in the breath for up to 72 hours.