GnRh agonist


Lupron is used to prepare the ovaries for stimulation with fertility medications. Lupron temporarily shuts down the messages from the brain to the pituitary gland, which then shuts down FSH and LH production. Without the production of these hormones, the ovaries can’t produce the necessary hormones to make eggs. When fertility medications are added Lupron allows the ovaries to grow multiple eggs and suppresses the selection process that only permits one egg a month to ovulate. It also prevents ovulation from occurring before the egg retrieval.

Side Effects

  • Headache
  • Irritability
  • Forgetfulness
  • Hot flashes
  • Night sweats
  • Vaginal dryness
  • Irritation at injection site
  • Ovarian cyst formation.

How medication is supplied

One 2.8 ml multi-dose vial. Does not require mixing. One vial yields 28 days of injection at a dose of 10 Units/day.

Route of administration

Subcutaneous injection once daily–in the morning using insulin syringe.

You will be given a prescription for Lupron 2.8 ml multidose vials (1mg/.2ml). Usually one vial will be enough for one treatment cycle. You will also be given a prescription for insulin syringes. Keep this medication refrigerated.

Microdose Lupron needs to be mail ordered from Schrafts or Freedom Drug.

Your starting dose of Lupron will be highlighted below:

  • Microdose Lupron 0.04 mg. (or 1cc, corresponding to 10 units using insulin suringe)
  • Lupron 1 mg (or .2cc, corresponding to 20 units using insulin syringe)
  • Lupron .5 mg (or .1cc, corresponding to 10 units using insulin syringe)
  • Lupron .25 mg (or .05cc, corresponding to 5 units using insulin syringe)

Getting started

  1. Wash and dry hands
  2. Supplies needed:
    • Medication
    • Gauze
    • Insulin Syringes
    • Band-aid
    • Alcohol swipe

Preparation of medication

  1. Remove plastic cover.
  2. Wipe the rubber stopper with alcohol.
  3. Draw back plunger to the 5, 10 or 20 unit mark on syringe as directed.
  4. Instill air into the vial and then draw back on the liquid in the syringe. Make sure air bubbles are out before removing needle from vial.

Administration of medication

  1. Expose thigh area or abdomen. Wipe area for injection with alcohol.
  2. Grasp or spread area for injection with thumb and first finger.
  3. Dart needle between the spread fingers at a 45 degree angle and inject the medication.
  4. Pull the needle out and rub area gently with gauze.
  5. Alternate sites daily.
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